| microRNAs在糖尿病视网膜病变中作用的研究进展 |
| |
| 引用本文： | 朱安民,谭薇. microRNAs在糖尿病视网膜病变中作用的研究进展[J]. 国际眼科杂志, 2022, 22(3): 403-406 |
| |
| 作者姓名： | 朱安民 谭薇 |
| |
| 作者单位： | 563000 中国贵州省遵义市,遵义医科大学第三附属医院眼科 |
| |
| 基金项目： | 国家自然科学基金资助项目(No.81660162); 贵州省科技计划项目{No.黔科合基础〖2020〗1Y327}; 贵州省卫生健康委科学技术基金项目(No.gzwjkj2020-1-155) |
| |
| 摘 要： | microRNAs(miRNAs)是一种具有调节基因表达功能的非编码小RNA分子,可以在包括血清或血浆在内的许多生物液中由细胞和组织释放.大量研究已经证实不同的miRNAs在糖尿病视网膜病变(DR)中的表达可特异性增高或减少,最近越来越多的证据表明血清和血浆中某些miRNAs在DR中存在特异性表达并参与DR的发生发展,...
|
| 关 键 词： | microRNAs 糖尿病视网膜病变 生物标志物 诊断 疾病进展 治疗 |
| 收稿时间： | 2021-04-10 |
| 修稿时间： | 2022-01-20 |
Research progress on the role of microRNAs in diabetic retinopathy |
| |
| An-Min Zhu and Wei Tan. Research progress on the role of microRNAs in diabetic retinopathy[J]. International Eye Science, 2022, 22(3): 403-406 |
| |
| Authors: | An-Min Zhu and Wei Tan |
| |
| Affiliation: | Department of Ophthalmology, the Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China and Department of Ophthalmology, the Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, Guizhou Province, China |
| |
| Abstract: | The microRNAs(miRNAs)is a non-coding small RNA molecule with the function of regulating gene expression, which can be released by cells and tissues in various biological fluids, including serum or plasma. A large number of studies have confirmed that the expression of different miRNAs in diabetic retinopathy(DR)can be specifically increased or decreased. Recently, more and more evidence shows that some miRNAs in serum and plasma are specifically expressed in DR and participate in the occurrence and development of DR, and can become biomarkers for the diagnosis of DR and monitoring of DR progress. In addition, the regulation of these miRNAs levels may delay the progression of DR for early intervention in patients with DR. miRNAs is expected to become a new therapeutic target for DR. This paper mainly reviews the progress of miRNAs in the diagnosis and monitoring of DR and possible new therapeutic targets in recent years. |
| |
| Keywords: | microRNAs diabetic retinopathy biomarkers diagnosis disease progression treatment |
| 本文献已被 维普 万方数据 等数据库收录！ |
| 点击此处可从《国际眼科杂志》浏览原始摘要信息 |
|
点击此处可从《国际眼科杂志》下载全文 |
