| 聚糖在肿瘤转移、免疫调节和治疗中的特定作用 |
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| 作者姓名： | 聂笔爻 戴蓓英 杨勇 王琛 |
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| 作者单位： | 1.中国药科大学生命科学与技术学院，江苏 南京 211198;2.中国药科大学药物科学研究院，江苏 南京 211198;3.中国药科大学基础医学与临床药学学院，江苏 南京 211198 |
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| 基金项目： | 国家自然科学基金（No.82002971） |
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| 摘 要： | 聚糖与糖基化修饰对调节细胞功能至关重要,异常的糖基化修饰和聚糖含量或组成的改变可加速癌细胞的恶性转化,促进肿瘤转移并参与调节机体的抗肿瘤免疫反应,最终促进肿瘤发展.因此,研究肿瘤细胞相关糖基化和聚糖的异常表达对了解肿瘤的发生发展具有重要意义.本文旨在阐明糖基化和聚糖改变与肿瘤进展之间的密切联系并总结相关最新糖基化治疗策...
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| 关 键 词： | 癌症 聚糖 糖基化 转移 免疫调节 |
The specific role of glycans in tumor metastasis, immune regulation and treatment |
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| Authors: | NIE Biyao DAI Peiying YANG Yong WANG Chen |
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| Institution: | (School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,China;Institute of Pharmaceutical Sciences,China Pharmaceutical University,Nanjing 211198,China;School of Basic Medicine and Clinical Medicine,China Pharmaceutical University,Nanjing 211198,China) |
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| Abstract: | Glycan and glycosylation is essential for regulating cell function, abnormal glycosylation modification and changes in glycan content or composition can accelerate the malignant transformation of cancer cells, promote tumor metastasis, participate in the regulation of the organism''s anti-tumor immune response, which ultimately promotes tumor development. To understand the occurrence and development of tumors, studying tumor-related glycosylation and abnormal glycans expression is of great significance. Therefore, this essay aims to clarify the relationship between glycosylation and tumor development and summarize the latest related glycosylation treatment strategies, which will provide new ideas and approaches for tumor treatment. |
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| Keywords: | Cancer Glycan Glycosylation Metastasis Immune modulation |
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