从基质黏弹性和钙信号深入理解骨性关节炎发病机制

近年来,科学家们普遍认为细胞外基质(extracellular matrix,ECM)力学特性是调控细胞力学生物学行为的一个重要影响因素.几乎所有的活组织和ECM都具有显著的黏弹性特征.大量研究证实,细胞能够感受和响应ECM力学特性.细胞通过基于整合素的黏附、力敏感离子通道激活以及下游信号通路的激活来感受基质力学特性的...

Deeper Understanding the Pathogenesis of Osteoarthritis from Matrix Viscoelasticity and Calcium Signaling

Generally, extracellular matrix (ECM) has the characteristics of viscoelasticity. In osteoarthritis (OA), catabolic processes alter the viscoelastic properties of functional pericellular matrix (PCM) of chondrocytes. Chondrocytes sense and respond to their mechanical microenvironment via an array of mechanosensitive receptors and channels that activate a complex network of downstream signaling pathways to regulate several cell processes central to OA pathology. Advances in understanding the specific mechanosignalling mechanisms in articular cartilage will promote the development of cell microenvironment construction in cartilage tissue engineering and the targeted precision therapeutics for OA. In this review, the work on the mechanism of matrix viscoelasticity regulating chondrocytes mechanotransduction by Agarwal et al. was briefly commented, and the recent advances related with their work was also discussed.