| 胸腔灌注大剂量TNF治疗恶性胸水 |
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| 引用本文： | 华新民,吴清泽,段贵新,徐力,任宪伟,刘建阳,王启文,卢卫平.胸腔灌注大剂量TNF治疗恶性胸水[J].中国肿瘤临床,1996,23(4):263-265. |
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| 作者姓名： | 华新民 吴清泽 段贵新 徐力 任宪伟 刘建阳 王启文 卢卫平 |
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| 作者单位： | 吉林省肿瘤医院 |
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| 摘 要： | ２４例由组织学或／和细胞学诊断的恶性胸腔积液，经胸腔内灌注相当４倍机体最大耐受剂量（ＭＴＤ）的肿瘤坏死因子（ＴＮＦ４×１０６单位）进行治疗，ＣＲ１８例，ＰＲ４例，ＮＣ２例，有效缓解率９１．７％（２２／２４）。毒副反应：高热１６例（６６．７％），疼痛１４例（５８．３％），经对症处理可缓解。与其他胸水治疗方法比较，该方法具有疗效高，毒副反应低的特点。
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| 关 键 词： | 恶性胸腔积液，药物疗法，坏死因子，肺肿瘤 |
The Evaluation of High Dose TNF Instillation Intrapleurally in the Management of Malignant Pleural Effusion |
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| Hua Xin-Min, Wu Qing-Ze,Duan Gui-Xin et al.The Evaluation of High Dose TNF Instillation Intrapleurally in the Management of Malignant Pleural Effusion[J].Chinese Journal of Clinical Oncology,1996,23(4):263-265. |
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| Authors: | Hua Xin-Min Wu Qing-Ze Duan Gui-Xin |
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| Abstract: | Twenty four cases with malignant pleural effusion confirmed either histologically or by cytology were treated by tumor necrosis factor(TNF)instillation 4 times the dosage of routine maximum tolerance dosage.CR was achieved in 18 cases,PR in 4 cases,NC in 2 cases. The overall response rate was 91.7%(22/24).Side reactions consisted of high fever in 16 cases(66. 7%),Chest pain in 14 cases (58.3%)which were relieved by appropriate measures.This approach of therapy was superior to other modalities of managements in terms of high efficacy and lower toxicity. |
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| Keywords: | Malignant pleural effusion High dosage of tumor Tumor necrosis factor instillation lung cancer Intrapleural instillation |
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