独一味滴丸一般药理学实验研究

目的为进一步探讨独一味滴丸的安全性,观察了独一味滴丸的一般药理作用,以供临床用药参考。方法观察Bealge犬麻醉状态下,独一味滴丸对Bealge犬血压、呼吸频率、呼吸振幅和心电图标准Ⅱ导联的影响;独一味滴丸对小鼠自发活动的影响;对戊巴比妥钠阈剂量致小鼠睡眠时间的影响;对戊巴比妥钠阈下剂量致小鼠催眠有无明显协同作用;对小鼠的转棒运动有无明显的影响。结果独一味滴丸在516 mg(原料药)/kg体重给药剂量内,对麻醉Bealge犬心血管系统和呼吸系统均无明显影响;在688 mg(原料药)/kg体重给药剂量范围内,对小鼠的中枢神经系统没有明显的抑制作用,对小鼠的机能协调运动也无明显影响。结论一般药理作用研究表明,独一味滴丸对动物心血管系统、呼吸系统及中枢神经系统均无明显影响,提示其不良反应小。

Study on the General Pharmacological Effects of DuYiwei Dripping Pill

Objective To further study the safety of DuYiwei Dripping Pill and to observe the general pharmacological effects for the reference of clinical therapy.Methods To observe the effects of DuYiwei Dripping Pill on Bealge canine blood pressure,respiratory and ECG.In the state of paralysis,and the effects of DuYiwei Dripping Pill on rats central and somatic motion nerves.Results Within a dose of 516mg/kg,it had no obvious action on canine cardiovascular systems and respiratory system.Within a dose of 688mg/kg,it didn' t inhibit the central nervous system(CNS) of rats clearly,and it didn' t affect the harmonious motion of rats' function either.Conclusion The result indicates that within the above-mentioned dose of DuYiwei Dripping Pill,it has no effect on animal' s cardiovascular systems,respiratory system and CNS.It exerts that the systematic side of DuYiwei Dripping Pill is little.