Antidiarrhoeal activity of seed extract of Albizzia lebbeck Benth |
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Authors: | Besra S E Gomes A Chaudhury L Vedasiromoni J R Ganguly D K |
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Institution: | Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, Calcutta 700 032, India. |
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Abstract: | The antidiarrhoeal activity of the seed extract of Albizzia lebbeck (Benth.) was investigated employing conventional rodent models of diarrhoea, i.e. castor oil-induced diarrhoea, upper gastrointestinal transit (u.g.t.) and fluid secretion. It was found that the aqueous methanol extract of Albizzia lebbeck seeds (2.5-5 mg/kg i.p.) possessed antidiarrhoeal activity which strengthens the earlier use of the seeds in the treatment of diarrhoea and dysentery. The antidiarrhoeal dose of the extract was at least 10-30 times less than the LD(50) dose. The extract (2.5-5 mg/kg i.p.) potentiated the antidiarrhoeal activity of loperamide (1 mg/kg i.p.). Nalaxone (0.5 mg/kg i.p.) significantly inhibited the antidiarrhoeal activity of the extract as well as loperamide, thus indicating a role of the opioid system in the antidiarrhoeal activity of the extract. |
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Keywords: | Albizzia lebbeck seed extract antidiarrhoeal activity |
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