| Bcl-2和Bax表达在乳腺浸润性导管癌细胞凋亡中的作用 |
| |
| 引用本文： | 黄平,杨光伦,姚榛祥,涂刚.Bcl-2和Bax表达在乳腺浸润性导管癌细胞凋亡中的作用[J].中华肿瘤防治杂志,2003,10(2):131-132. |
| |
| 作者姓名： | 黄平 杨光伦 姚榛祥 涂刚 |
| |
| 作者单位： | 重庆医科大学临床学院普外科,重庆,400016 |
| |
| 摘 要： | 目的 :探讨Bcl 2和Bax表达在乳腺浸润性导管癌细胞凋亡过程中的作用。方法 :用免疫组织化学方法检测 18例乳腺浸润性导管癌及癌旁组织中Bcl 2和Bax的表达 ,用TUNEL法检测乳腺组织中细胞凋亡。结果 :乳腺浸润性导管癌与癌旁组织比较 ,凋亡细胞明显减少 ,癌组织及癌旁组织中Bcl 2的阳性表达分别为 15 18和 6 18,差异有极显著性 (P <0 0 1) ;Bax的阳性表达分别为 8 18和 14 18,差异有显著性 (P <0 0 5 )。结论 :Bcl 2和Bax在乳腺浸润性导管癌的细胞凋亡调控中有重要作用
|
| 关 键 词： | 癌 浸润性导管/病理学 基因 Bcl-2 原癌基因蛋白质类 乳腺肿瘤/病理学 免疫组织化学 |
| 文章编号： | 1009-4571(2003)02-0131-02 |
| 修稿时间： | 2001年12月31 |
Expression of Bcl-2 and Bax on Apoptosis in Breast Invasive Ductal Carcinoma |
| |
| HUANG Ping,YANG Guang-lun,YAO Zhen-xiang,et al..Expression of Bcl-2 and Bax on Apoptosis in Breast Invasive Ductal Carcinoma[J].Chinese Journal of Cancer Prevention and Treatment,2003,10(2):131-132. |
| |
| Authors: | HUANG Ping YANG Guang-lun YAO Zhen-xiang |
| |
| Institution: | HUANG Ping,YANG Guang-lun,YAO Zhen-xiang,et al.Department of General Surgery,College of Clinical Medicine of Chongqing Medical University,Chongqing 400016,China |
| |
| Abstract: | Objective To investigate the expression of Bcl-2 and Bax in the apoptotic process of breast invasive ductal carcinoma.Methods Both carcinoma tissues and their surrounding tissues from 18 patients with breast invasive ductal carcinomas were examined for the expression of Bcl-2 and Bax by immunohistochemical staining. Apoptosis was examined by TUNEL.Results The apoptotic index in breast invasive ductal carcinoma was significantly lower than that of tissues surrounding carcinomas.In breast invasive ductal carcinoma,the expression of Bcl-2 was significantly higher than that of tissues surrounding carcinomas (15/18 vs 6/18,P<0.01).However,the expression of Bax was significantly lower(8/18 vs 14/18,P<0.05).Conclusion Bcl-2 and Bax may play an important role in regulation of apoptosis in breast invasive ductal carcinoma. |
| |
| Keywords: | carcinoma infiltrating duct/pathology genes bcl-2 proto-oncogene proteins breast neoplasms/pathology immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
