| 槲皮素止泻机制研究 |
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| 引用本文： | 张文举,陈宝田,王彩云,朱全红,莫志贤. 槲皮素止泻机制研究[J]. 南方医科大学学报, 2003, 23(10): 1029-1031 |
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| 作者姓名： | 张文举 陈宝田 王彩云 朱全红 莫志贤 |
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| 作者单位： | 第一军医大学中医系,广东,广州,510515 |
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| 基金项目： | 国家自然科学基金(39970912)，广东省中医药管理局资助课题(970241)~~ |
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| 摘 要： | 目的研究番石榴叶提取物槲皮素止泻的作用机制。方法观察槲皮素对豚鼠离体回肠收缩活动的影响和对小鼠小肠推进功能的影响,记录其收缩力和推进距离;观察槲皮素对腹腔毛细血管通透性的抑制作用。结果槲皮素抑制离体回肠的收缩,抑制小肠的推进功能,抑制毛细血管的通透性。结论槲皮素能通过抑制肠道的蠕动、抑制肠道毛细血管的通透性来发挥其止泻作用,这也是番石榴叶止泻机制之一。
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| 关 键 词： | 槲皮素 番石榴叶 腹泻 |
| 文章编号： | 1000-2588(2003)10-1029-03 |
| 修稿时间： | 2003-04-01 |
Mechanism of quercetin as an antidiarrheal agent |
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| ZHANG Wen-ju,CHEN Bao-tian,WANG Cai-yun,ZHU Quan-hong,MO Zhi-xian. Mechanism of quercetin as an antidiarrheal agent[J]. Journal of Southern Medical University, 2003, 23(10): 1029-1031 |
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| Authors: | ZHANG Wen-ju CHEN Bao-tian WANG Cai-yun ZHU Quan-hong MO Zhi-xian |
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| Affiliation: | ZHANG Wen-ju,CHEN Bao-tian,WANG Cai-yun,ZHU Quan-hong,MO Zhi-xian Department of Traditional Chinese Medicine,First Military Medical University,Guangzhou 510515,China |
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| Abstract: | Objective To investigate the antidiarrheal mechanism of quercetin extracted from Psidium guajava L. Methods The effects of quercetin on the contractility of guinea pig ileum in vitro and on the peristaltic motion of mouse small intestine in vivo were observed, and the peak value of contractility and peristaltic distance recorded. The inhibitory effect of quercetin on the permeability of the abdominal capillaries was also observed. Results Quercetin inhibited the contraction of guinea pig ileum in vitro and the peristaltic motion of mouse small intestine, and reduced the permeability of abdominal capillaries. Conclusion Quercetin can inhibit the intestinal movement and reduce capillary permeability in the abdominal cavity, which may be the antidiarrheal mechanism of Psidium guajava L extract. |
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| Keywords: | quercetin Psidium guajava leaf diarrhea |
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