C反应蛋白与冠心病的关系探讨

目的评价C反应蛋白（CRP）与冠心病（CHD）的关系。方法2005年11月至2006年6月心脏内科收治稳定性心绞痛（SAP）、不稳定性心绞痛（UAP）、急性非S-T段抬高型心肌梗死、急性心肌梗死（AMI）患者共166例，以及正常体检人员24例。发病24h内测定CRP血清浓度，随访患者0～35d的心脏事件发生率。结果不同临床类型冠心病CRP浓度与正常对照组比较有显著性差异（P〈0．01），各组CRP浓度也有显著性差异（P〈0．01）。结论CRP不仅参与冠心病的发生与发展，且其血清浓度越高，临床情况越重、预后越差，心脏事件发生率越高。

The reationship between C-reactive protein and coronary heart disease

Objective To evaluate the relationship between C-reactive protein(CRP) and coronary heart disease(CHD) and its cardiac events.Methods The data of 166 patients with stable angina pectoris(SAP),unstable angina pectoris(UAP),acute no S-T segment elevation myocardial infarction or acute myocardial infarction(AMI)from November 2005 to June 2006 were collected and compared with 24 normal persons for physical examination.The relation of blood serum density of CRP in 24-hours from onset and incidence of heart event followed up 35 days was evaluated.Results Compared with normal control group,the expressions of CRP in different clinical type of CHD were significant differences(P<0.01),and expressions of CRP among different clinical type were also significant differences(P<0.01).Conclusions CRP may play an important role in generation and development of CHD,and the high level of CRP can lead to severe clinical situation,bad prognosis and high incidence of heart events.