Nonrandom chromosomal changes in untreated retinoblastomas |
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| Authors: | William F. Benedict Ashutosh Banerjee Corey Mark A. Linn Murphree |
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| Affiliation: | 1. Clayton Ocular Oncology Center, Childrens Hospital of Los Angeles, Los Angeles USA.;2. Divisions of Hematology-Oncology and Ophthalmology, Childrens Hospital of Los Angeles, Los Angeles USA.;3. Departments of Pediatrics and Ophthalmology, University of Southern California School of Medicine, Los Angeles USA. |
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| Abstract: | The karotypic patterns of 15 retinoblastomas were examined. Five tumors were found to have two distinct stem lines and, therefore, the chromosomal patterns of 20 tumor cell lines are reported. Three nonrandom chromosomal changes, namely, a loss of a chromosome #13, the presence of an i(6p), or a trisomy of 1q were observed. The potential importance of these chromosomal changes in tumor development is discussed, particularly the loss of a chromosome #13 or the gain of an i(6p). At least one of the three chromosomal changes was found in 75% of the tumor lines analyzed. |
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| Keywords: | Address requests for reprints to William F. Benedict M.D. Division of Hematology-Oncology Childrens Hospital of Los Angeles 4650 Sunset Blvd. Los Angeles CA 90027. |
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