Founder mutations in <Emphasis Type="Italic">BRCA1/2</Emphasis> are not frequent in Canadian Ashkenazi Jewish men with prostate cancer期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Founder mutations in BRCA1/2 are not frequent in Canadian Ashkenazi Jewish men with prostate cancer

Authors:	Nancy?Hamel author-information" > author-information__contact u-icon-before" > mailto:nancy.hamel@mail.mcgill.ca" title=" nancy.hamel@mail.mcgill.ca" itemprop=" email" data-track=" click" data-track-action=" Email author" data-track-label=" " >Email author,Kimberley?Kotar,William?D?Foulkes

Affiliation:	1.Program in Cancer Genetics, Departments of Oncology and Human Genetics,McGill University,Montreal,Canada;2.Research Institute of the McGill University Health Center,McGill University,Montreal,Canada;3.Cancer Prevention Centre,Sir MB Davis, Jewish General Hospital, McGill University,Montreal,Canada

Abstract:	Background Relatives of BRCA1 and BRCA2 mutation carriers have long been proposed by epidemiological studies to have an increased risk of developing prostate cancer. In the Ashkenazi Jewish (AJ) population, the existence of 3 frequent founder mutations, 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 greatly facilitates screening for carriers.

Keywords:
本文献已被 SpringerLink 等数据库收录！