| RD1/ESX-1分泌系统与结核分枝杆菌的毒力和致病性 |
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| 引用本文： | 秦紫芳,鲍朗.RD1/ESX-1分泌系统与结核分枝杆菌的毒力和致病性[J].国际流行病学传染病学杂志,2008,35(3). |
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| 作者姓名： | 秦紫芳 鲍朗 |
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| 作者单位： | 四川大学华西基础医学与法医学院感染与免疫研究室,成都,610041 |
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| 摘 要： | 结核分枝杆菌(MTB)全基因序列测定的完成和比较基因组学的发展,使得对MTB毒力和致病机制的认识不断深入,近年发现RDI区在MTB的致病机制中充当重要角色,而RDI区编码的ESX-1蛋白组成的分泌转运系统与MTB的毒力关系密切.此文主要从MTB RD1/ESX-1蛋白分泌转运系统对ESAT-6/CFP-10分泌输出的影响,探讨其与MTB的毒力和致病机制的关系.
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| 关 键 词： | 分枝杆菌 结核 毒力蛋白分泌 |
RD-1/ESX-1 secretion system for the virulence and pathogenisis of Mycobacterium tuberculosis |
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| QIN Zi-fang,BAO Lang.RD-1/ESX-1 secretion system for the virulence and pathogenisis of Mycobacterium tuberculosis[J].International Journal of Epidemiology and Infectious Disease,2008,35(3). |
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| Authors: | QIN Zi-fang BAO Lang |
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| Abstract: | The availability on the complete genome sequence of M.tuberculosis(MTB)and the development of the comparative genomics,have led to important advances in understanding the pathogenesis of tuberculosis.An important role with RD1 of genome in MIB pathogenesis has been demonstrated.and the secretion-transport system which is composed of ESX-1 proteins encoded by MTB RD1 locus is in close relation with the virulence of MTB.THis text mainly describes the influence of the secretion-transport system of MTB RD1/ESX-1 on the secretion and export of ESAT-6/CFP-10,so as to investigate the relation between the secretion-transport system and the virulence and pathogenesis of MTB. |
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| Keywords: | RD1 ESX-1 |
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