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米托蒽醌为主的化疗方案对CD34+高表达急性髓细胞性白血病疗效观察
引用本文:凌云,曹祥山,邱国强,谢晓宝,刘琰,顾伟英,钱新瑜. 米托蒽醌为主的化疗方案对CD34+高表达急性髓细胞性白血病疗效观察[J]. 临床血液学杂志, 2005, 18(2): 84-86
作者姓名:凌云  曹祥山  邱国强  谢晓宝  刘琰  顾伟英  钱新瑜
作者单位:凌云(常州市第一人民医院,苏州大学附属第三医院血液科,江苏常州,213003)      曹祥山(常州市第一人民医院,苏州大学附属第三医院血液科,江苏常州,213003)      邱国强(常州市第一人民医院,苏州大学附属第三医院血液科,江苏常州,213003)      谢晓宝(常州市第一人民医院,苏州大学附属第三医院血液科,江苏常州,213003)      刘琰(常州市第一人民医院,苏州大学附属第三医院血液科,江苏常州,213003)      顾伟英(常州市第一人民医院,苏州大学附属第三医院血液科,江苏常州,213003)      钱新瑜(常州市第一人民医院,苏州大学附属第三医院血液科,江苏常州,213003)
摘    要:目的:探索米托蒽醌(MTZ)在急性髓细胞性白血病(AML)化疗中的作用特点,提高AML的疗效和无病生存率(FDS)。方法:80例免疫分型中有CD34^ 抗原高表达的AML,随机选择(MA/MAE、DA/DAE和HA/HAE)方案,联合化疗1~2个疗程后分别比较CR率、骨髓抑制及其它毒副作用;同时对白血病细胞进行体外药物杀伤效应实验,分别比较MTZ、柔红霉素(DNR)、高三尖杉酯碱(HHT)对白血病细胞不同分化阶段的抑制作用。结果:CD34抗原高表达的AML中,1~2个疗程CR率,以MA/MAE方案最高。为80.0%(24/30).白血病细胞体外药物杀伤实验显示,MTZ对CD34^ 高表达的AML的抑制显著高于DNR和HHT。结论:MTZ具有较强的抗AML活性,临床骨髓抑制明显上述特点可能与其主要作用于AML白血病细胞的分化较早阶段有关。

关 键 词:白血病,急性 米托蒽醌 CD34^+
文章编号:1004-2806(2005)02-0084-03
修稿时间:2004-09-28

The clinical studies of mitoxantrone in acute myelogenous leukemia with high percentage of CD34+
LING Yun,CAO Xiangshan,QIU Guoqiang,XIE Xiaobao,LIU Yan,GU Weiying,QIAN Xinyu. The clinical studies of mitoxantrone in acute myelogenous leukemia with high percentage of CD34+[J]. Journal of Clinical Hematology, 2005, 18(2): 84-86
Authors:LING Yun  CAO Xiangshan  QIU Guoqiang  XIE Xiaobao  LIU Yan  GU Weiying  QIAN Xinyu
Abstract:Objective:To investigate the character of antitumor effects of mitoxantrone (MTZ) and increase the remission rate and disease-free survivals (DFS) in acute myelogenous leukemia (AML).Method:80 AML patients with high percentage CD34+ was randomly divided into receiving MA/MAE, DA/DAE or HA/HAE induction chemotherapy regimen and evaluate the efficacy and safety. The killing effects of MTZ were investigated by in vitro culturing leukemia cells from patients through MTT assay.Result:there are 80.0%(24/30) of patients in AML with regimen MA/MAE achieved remission after induction alone, higher remission rate than those regimens containing DNR and HTT. A Higher inhibition on leukemia cells with high percentage of CD34+ in vitro was seen with MTZ than with DNR and HTT.Conclusion:MTZ had a strong anti-leukoumia effect. The significant bone marrow suppression of MTZ might relate with MTZ's effect mainly on early differentiation phase of leukemia cell.
Keywords:Leukemia  Mitoxantrone  CD34+
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