Effect of lycoriside,an acylglucosyloxy alkaloid,on mast cells |
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Authors: | Ghosal Shibnath Shanthy Amirthalingam Mukhopadhyay Mita Sarkar Mihir K Das Prasun K |
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Institution: | (1) Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Banaras Hindu University, Varanasi, 221005, India;(2) Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India |
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Abstract: | The effect of lycoriside, an acylglucosyloxy alkaloid from Crinum asiaticum Linn, (family Amaryllidaceae), with or without sitosterol-3-O- -D-glucoside, was studied on the rate of degranulation of peritoneal mast cells of albino rats. Lycoriside, at lower concentrations (1–20 µg/ml), in vitro, produced statistically significant protection against Tween 80-induced degranulation, as also to sensitized mast cells challenged with an antigen (horse serum). It also provided protection against compound 48/80-induced degranulation of mast cells when administered in vivo (1–5 mg/kg, po). At higher concentrations (100 µg/ml and above), in vitro, however, it had a mast-cell degranulation effect per se. The addition of sitosterol-3-O- -D-glucoside to lycoriside did not modify the effect of the latter compound. The mechanism of the dual response elicited by lycoriside is appraised in view of a concentration-dependent anti- or prerelease effect on mast-cell mediators. |
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Keywords: | Crinum asiaticum amaryllidaceae lycoriside acylglycosyloxy alkaloids mast cell degranulation |
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