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Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma
Authors:Veronica Veschi  Zhihui Liu  Ty C. Voss  Laurent Ozbun  Berkley Gryder  Chunhua Yan  Ying Hu  Anqi Ma  Jian Jin  Sharlyn J. Mazur  Norris Lam  Barbara K. Souza  Giuseppe Giannini  Gordon L. Hager  Cheryl H. Arrowsmith  Javed Khan  Ettore Appella  Carol J. Thiele
Affiliation:1. Cell and Molecular Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, CRC, 1-3940, 10 Center Drive MSC-1105, Bethesda, MD 20892, USA;2. High-Throughput Imaging Facility, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA;3. Oncogenomics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA;4. Center for Biomedical Informatics and Information Technology, Center for Cancer Research, National Cancer Institute, Rockville, MD 20850, USA;5. Department of Structural and Chemical Biology, Oncological Sciences, Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;6. Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada;7. Chemical Immunology Section, Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD 20892, USA;8. Laboratory of Receptor Biology and Gene Expression, Center for Cancer Research, National Institutes of Health, Bethesda, MD 20892, USA;9. Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Molecular Medicine, University La Sapienza, 00161 Rome, Italy
Abstract:
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  • Keywords:SETD8  p53  neuroblastoma  epigenetics  differentiation  siRNA screen
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