Outcomes associated with antibiotic regimens for treatment of Mycobacterium abscessus in cystic fibrosis patients |
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| Authors: | Alison DaCosta Cameron L Jordan Olivia Giddings Feng-Chang Lin Peter Gilligan Charles R Esther |
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| Institution: | 1. Department of Pharmacy Services, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27599, USA;2. Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;3. Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;4. Clinical Microbiology-Immunology Laboratories, UNC Healthcare, Chapel Hill, NC 27599, USA |
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| Abstract: | BackgroundMycobacterium abscessus infection is associated with declining lung function in cystic fibrosis (CF), but there is little evidence on clinical efficacy to guide treatment.MethodsRetrospective review of 37 CF patients treated for M. abscessus respiratory infection at a single center from 2006 to 2014. Outcomes included change in FEV1 at 30, 60, 90, 180, and 365 days after treatment and clearance of M. abscessus from sputum cultures.ResultsLung function was significantly improved after 30 and 60 days of treatment, but not at later time points. Gains were inversely related to starting lung function. Antibiotic choices did not influence outcomes except for greater clearance with clarithromycin.ConclusionsTreatment of M. abscessus resulted in short term improvement in lung function that is inversely related to pre-treatment FEV1. |
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| Keywords: | Nontuberculous mycobacterium Cystic fibrosis |
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