Human Stimulus Factor Is a Promising Peptide for Delivery of Therapeutics |
| |
| Authors: | Mehra Haghi Norbert Windhab Benedikt Hartwig Paul M. Young Daniela Traini |
| |
| Affiliation: | 1. Respiratory Technology, Woolcock Institute of Medical Research, Sydney, Australia;2. Evonik Nutrition and Care GmbH, Kirschenallee, 64293 Darmstadt, Germany;3. Discipline of Pharmacology, Faculty of Medicine and Health, University of Sydney, Sydney, Australia |
| |
| Abstract: | Fluticasone propionate uptake in the presence of a proprietary cell-penetrating peptide (human stimulus factor, [HSF]) based on the N-terminal domain of lactoferrin was studied, alone and in combination with salmeterol, using an air interface Calu-3 epithelial model. The HSF enhanced uptake and transport of fluticasone propionate across the epithelial barrier when alone and in presence of salmeterol. This was attributed to transcellular-mediated uptake. This HSF is a promising peptide for delivery of therapeutics where enhanced epithelial penetrating is required. |
| |
| Keywords: | human stimulus factor cell-penetrating peptide inhaler cell transport corticosteroids |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
