Comparison of the ACC/AHA and Framingham algorithms to assess cardiovascular risk in HIV-infected patients |
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Authors: | Lauro Ferreira da Silva Pinto Neto Fernanda Rezende Dias Flavia Feres Bressan Carolina Rocio Oliveira Santos |
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Affiliation: | 1. Escola de Ciências da Santa Casa de Vitória, Unidade de Doenças Infecciosas, Vitória, ES, Brazil;2. Santa Casa de Misericórdia de Vitória, Vitória, ES, Brazil |
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Abstract: | The aim of this study was to compare the predictions of Framingham cardiovascular (CV) risk score (FRS) and the American College of Cardiology/American Heart Association (ACC/AHA) risk score in an HIV outpatient clinic in the city of Vitoria, Espirito Santo, Brazil. In a cross-sectional study 341 HIV infected patients over 40 years old consecutively recruited were interviewed. Cohen's kappa coefficient was used to assess agreement between the two algorithms. 61.3% were stratified as low risk by Framingham score, compared with 54% by ACC/AHA score (Spearman correlation 0.845; p < 0.000). Only 26.1% were classified as cardiovascular high risk by Framingham compared to 46% by ACC/AHA score (Kappa = 0.745; p < 0.039). Only one out of eight patients had cardiovascular high risk by Framingham at the time of a myocardial infarction event registered up to five years before the study period. Both cardiovascular risk scores but especially Framingham underestimated high-risk patients in this HIV-infected population. |
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Keywords: | Cardiovascular disease HIV Co-morbidities Non-AIDS events |
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