Impact of advanced exercise ECG analysis on cost of coronary artery disease management |
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| Authors: | Riccardo Bigi PhD Alberto Ferrando BSc Eva Pagano BSc Lauro Cortigiani MD Franco Merletti MD Cesare Fiorentini MD Dario Gregori PhD |
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| Affiliation: | 1. Cardiologist, Cardiology, Department of Medicine and Surgery, University School of Medicine, Milan, Italy;2. Researcher,;3. Cardiologist, Cardiovascular Unit, ‘Campo di Marte’ Hospital, Lucca, Italy;4. Professor, Unit of Cancer Epidemiology, CeRMS and CPO Piemonte, University of Turin, Turin, Italy;5. Head of Unit, Cardiology, Department of Medicine and Surgery, University School of Medicine and Centro Cardiologico Monzino IRCCS, Milan, Italy;6. Professor, Department of Environmental Medicine and Public Health, University of Padova, Padova, Italy |
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| Abstract: | Background Conventional analysis of exercise electrocardiogram (EX‐ECG) has limited accuracy. This study aims to evaluate the potential impact of improving EX‐ECG accuracy on costs of diagnosis and number of misdiagnoses of coronary artery disease (CAD). Methods A decision‐tree model was simulated including sequential application of diagnostic procedures for suspected CAD. The model was structured in two main branches (presence or absence of CAD). A probabilistic sensitivity analysis was then performed for several combinations of improvement in test sensitivity and specificity. Results A clear trend in cost reduction was observed at improving EX‐ECG specificity (about 8–8.5 million dollars, corresponding to a 5.6–7.6% reduction according to the prevalence level). Wrong diagnoses counted for 9–13% of test. Improvements in test parameters lead to reductions in wrong diagnoses, especially when increasing specificity (8.8–12.5%). Conclusions A proper improvement in EX‐ECG sensitivity and specificity would have a relevant impact on the costs of CAD management, while reducing the number of misdiagnoses. |
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| Keywords: | coronary disease cost analysis exercise test |
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