The ‘Sandwich Sign’ of Mesenteric Lymphoma

A proteomic approach was applied to study the protein expression profile of peripheral T‐cells derived from patients at the onset of different B‐lymphoproliferative diseases, because a rising interest in specific actions played by T‐cells in such pathologies has emerged. Decreased levels of profilin‐1 and cofilin‐1 and increased levels of coronin1A and prohibitin were found in patients, compared with healthy controls. The protein‐protein interaction network of these proteins was studied using a web‐based bioinformatics tool, highlighting the actin cytoskeleton regulation as the main biological process involved in peripheral T‐cells of such patients. Unsupervised cluster analysis of protein expression data shows that the recorded alteration of T‐cell proteome was specifically induced by B‐cell pathologies.