Acute human parvovirus B19 infection and nephrotic syndrome in patients with sickle cell disease |
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| Authors: | Lynn Quek Claire Sharpe Neelanjana Dutt Sue Height Marlene Allman Moji Awogbade David C Rees Mark Zuckerman Swee Lay Thein |
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| Affiliation: | 1. Department of Haematological Medicine;2. Department of Renal Medicine;3. King’s College London School of Medicine, Division of Gene and Cell Based Therapy;4. Department of Histopathology;5. Department of Virology, King’s College Hospital NHS Trust, Denmark Hill, London, UK |
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| Abstract: | Acute Human Parvovirus B19 (HPV B19) infection is the major cause of transient red cell aplasia (TRCA) and acute anaemia in patients with sickle cell disease (SCD). We report three cases of patients who developed nephrotic syndrome (NS) with chronic sequelae after initially presenting with HPV B19‐associated TRCA. There was no correlation between evidence of HPV B19 infection and impaired renal function in our cohort of adult sickle cell patients. This is consistent with a view that although NS is potentially a rare complication of symptomatic acute HPV B19 infection, exposure to HPV B19 is not associated with an increased risk of renal disease. |
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| Keywords: | parvovirus B19 nephrotic syndrome sickle cell |
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