Reliability of multiparametric prostatic MRI quantitative data in the evaluation of prostate cancer aggressiveness |
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Authors: | Haisam Atta Tarek M. Elsaba Hesham M. Hassan Moemen M. Hafez Hassan A. Aboellela Hisham Imam |
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Affiliation: | 1. Radiology Department, South Egypt Cancer Institute, Assiut University, Egypt;2. Pathology Department, South Egypt Cancer Institute, Assiut University, Egypt;3. Pathology Department, Faculty of Medicine, Assiut University, Egypt;4. Urology Department, Faculty of Medicine, Assiut University, Egypt;5. Radiology Department, Faculty of Medicine, Assiut University, Egypt |
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Abstract: | PurposeTo compare the quantitative data of multiparametric prostatic MRI with Gleason scores of histopathological analysis.Materials and methodsOne hundred twenty-two patients performed Multiparametric MRI of the prostate. Functional MRI quantitative data (including diffusion with mean ADC value and spectroscopic metabolic ratio) where the DWI is employing b 50, 400, 800, 1000 and 2000 sec/mm2 and multivoxel MR spectroscopy compared with of Gleason scores of histopathological results. Malignant cases are classified into three groups according to their Gleason score as group I with Gleason score ≤6, group II Gleason score 7, while Gleason score 8–10 stratified as Group III.ResultsThe histopathological analysis reveals 78 malignant cases and 44 benign Cases. The significant statistical difference between group I and the other two groups (p < 0.001) regarding the quantitative mean ADC value and metabolic spectroscopic ratio. No significant statistical difference between group II and III with p = 0.2 for mean ADC difference and p = 0.8 for the metabolic spectroscopic ratio with a weak negative correlation between ADCand Gleason score [rs = ?0.26] and significant positive correlation (p = 0.02) for MRSI metabolic ratio [rs = 0.2].ConclusionThe quantitative data of functional imaging of the prostate is reliable in evaluating prostatic cancer aggressiveness and proper construction of therapeutic plan. |
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Keywords: | mpMRI prostate cancer aggressiveness |
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