灵芝煎剂治疗亚稀褶黑菇中毒患者的临床观察

目的：探讨灵芝煎剂对亚稀褶黑菇中毒患者的治疗作用。方法：以前一年同种中毒病例ll例为对照(对照组给予输氧、输液等常规治疗)。治疗组14例在常规治疗基础上，加用灵芝煎剂口服。比较两组的临床疗效及反映肾脏损害的尿N-乙酰-β-D葡萄糖酐酶(NAG)、尿红细胞和尿蛋白、反映肝脏损害的血清ALT、反映心脏损害的血清AST等各项指标改变情况。结果：治疗组临床愈显率明显优于对照组(P＜0．01)；治疗组绝大部分病例尿红细胞在治疗24h后完全消失，尿蛋白也明显减少，而3项酶学指标第3天上升达高峰，以后逐渐下降；对照组各项指标则呈持续进行性上升，两组在相同时间各项指标比较，治疗组明显低于对照组，差异有显著性(P＜0．01)。结论：灵芝煎剂对亚稀褶黑菇有较好的治疗作用，能明显降低亚稀褶黑菇中毒的病死率。

Clinical Observation on Treatment of Russula Subnigricans Poisoning Patients by Ganoderma Lucidum Decoction

Objective:To observe the effect of Ganoderma lucidum decoction in treating Russula subnigricans poisoning (RSP) patients. Methods:The 14 patients of RSP in the treated group were treated with GLD (GLD, one dose was prepared by 100 g of Ganoderma lucidum decocted with water to 600 ml), on the base of conventional treatment, and 11 patients received conventional therapy in the previous year were taken as control. The clinical efficacy and parameters in them were compared, including the urine N-acetyl-D-glucosaminidase (NAG, which reflects the injury of kidney), the red blood cell and protein in urine, the alanine transaminase (ALT, which reflects the injury of liver), and the aspartate aminotransferase (AST, which reflects the injury of heart). Results:A better clinical cure-markedly improving rate was showed in the treated group as compared with the control group, P<0.01. In the treated group, red blood cell in urine disappeared after 24hrs treatment in the majority of patients, urinary protein reduced obviously and the other three parameters reached the peak at the 3rd day then lowered gradually. In the control group, all the parameters increased continuously. Comparison between the parameters at corresponding time in the two groups showed significant difference (P<0.01), those in the treated group were markedly lower than those in the control group respectively. Conclusion:GLD has good effect in treating RSP, could obviously lower the fatal rate of RSP.