难治性癫痫中谷氨酸脱羧酶抗体的测定

目的　研究难治性癫痫与血清谷氨酸脱羧酶抗体 (GAD-A)水平的关系 ,探讨难治性癫痫的发病机制。方法　应用酶联免疫吸附法 (EL ISA)测定了 3 0例难治性癫痫和 3 0例完全缓解的癫痫患者血清 GAD-A水平。结果　难治性癫痫患者和完全缓解癫痫患者血清 GAD-A水平无显著性差异 (P>0 .0 5) ,并且 ,各种类型癫痫患者其 GAD-A亦无明显差异 (P>0 .0 5)。结论　 GAD-A与难治性癫痫无明确的相关性 ,需要进一步扩大规模研究难治性癫痫中的谷氨酸脱羧酶抗体的变化

Autoantibodies to glutamic acid decarboxylase in patients with intractable epilepsy

Objective To study the relationship between the le ve ls of autoantibodies to glutamic acid decarboxylase (GAD-A) and intractable epi lepsy in order to explore the pathogenic mechanisms of intractable epilepsy.Methods The authors investigated the prevalence of GAD-A in patien ts with intractable epilepsy (n=30) and controlled epilepsy (n=30) by en zyme-linked immunosorbent assay(ELISA).Results There was no si gnificant difference in the levels of GAD-A between patients with intractable a nd controlled epilepsy.Among the different seizure types,there was no significan t difference either.Conclusion There is no significant relatio nship between GAD-A and intractable epilepsy.Larger scale studies,perhaps compa ring different epilepsy syndromes,are required to determine the exact clinical r ole of GAD-A in intractable epilepsy.