前列地尔对非胰岛素依赖型糖尿病病人胰岛素及血小板聚集率的影响

目的：探讨前列地尔对非胰岛素依赖型糖尿病（ＮＩＤＤＭ）病人胰岛素及血小板聚集率的影响。方法：应用前列地尔２００μｇ加入０．９％氯化钠注射液５００ｍＬ中静脉滴注，ｑｄ×１０ｄ，治疗５０例ＮＩＤ ＤＭ病人（男性２３例，女性２７例，年龄５８±ｓ１０ａ）。治疗前后测定空腹胰岛素、餐后２ｈ胰岛素及血小板聚集率。结果：前列地尔刺激胰岛素分泌增加和降低血小板聚集率。治疗后的餐后２ｈ胰岛素显著增加（Ｐ＜０．０１），血小板聚集率显著下降（Ｐ＜０．０１，Ｐ＜０．０５）。结论：前列地尔增加ＮＩＤＤＭ病人的胰岛素分泌，降低血小板聚集率

Effects of alprostadil on insulin secretion and platelet aggregation in patients with non-insulin-dependent diabetes mellitus

AIM: To explore the effects of alprostadil on insulin secretion and platelet aggregation in patients with non-insulin-dependent diabetes mellitus(NIDDM). METHODS: Fifty patients (M 23, F 27; age 58±s 10 a) with NIDDM were treated with alprostadil 200 μg in 0.9% sodium chloride 500 mL, iv drip, qd, for 10 d. The insulin and platelet aggregation were measured before and after treatment. RESULTS: Alprostadil stimulated insulin secretion increment and decreased platelet aggregation. After treatment with alprostadil, 2 h postprandial insulin increased (P<0.01) and platelet aggregation decreased (P<0.05, P<0.01) in patients with NIDDM. CONCLUSION: Alprostadil may not only increase the insulin secretion, but also decrease the platelet aggregation in patients with NIDDM.