| 急性脑缺血再灌流后脑组织钙依赖中性蛋白酶的变化 |
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| 引用本文： | 彭凯润,张幸运. 急性脑缺血再灌流后脑组织钙依赖中性蛋白酶的变化[J]. 中国临床神经科学, 1994, 2(4): 218-220 |
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| 作者姓名： | 彭凯润 张幸运 |
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| 作者单位： | 广州军区广州总医院神经内科 510010(彭凯润，张幸运，石尚金)，广州军区广州总医院神经内科 510010(张松) |
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| 摘 要： | 本文采用大鼠全脑缺血模型,观测脑缺血再灌流脑组织Ca~(2 )依赖性中性蛋白酶(calci-um-activated neutral proteinase,calpain)活性的变化及海马C_(A1)区神经元损害改变。结果显示脑缺血再灌流脑组织calpain Ⅰ和calpain Ⅱ活性都明显升高(P<0.01),C_(A1)区神经元密度相应下降,提示calpains在脑缺血损害过程中可能起一定作用。
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| 关 键 词： | 脑组织 再灌流 钙依赖性中性蛋白酶 海马 |
Change in the Brain Calpains Activity Following Acute Cerebral Ischemia in Rat |
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| Peng Kai-Run,Zhang Xing-Yun,Shi Shang-Jin,Zhang Song. Change in the Brain Calpains Activity Following Acute Cerebral Ischemia in Rat[J]. Chinese Journal of Clinical Neurosciences, 1994, 2(4): 218-220 |
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| Authors: | Peng Kai-Run Zhang Xing-Yun Shi Shang-Jin Zhang Song |
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| Affiliation: | Peng Kai-Run,Zhang Xing-Yun,Shi Shang-Jin,Zhang Song Department of Neurology,General Hospital of Guangzhou Unit of PLA,Guangzhou |
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| Abstract: | We have investigated the changes of calcium-activated neutral proteinases (calpains) activity during reperfusion after transient cerebral ischemia by using the four-vessel occlusion model of ischemia in rat. The results indicated that calpain I and calpain I activities increased significantly and neuronal density of the CAI region of the hippocampus decreased correspondently. It is concluded that calpains may be responsible for ischemic damage to the brain. |
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| Keywords: | Cerebral ischemia Reperfusion Calpain Hippocampus |
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