Five Simultaneous Primary Tumors in a Single Patient: A Case Report and Review of the Literature |
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| Authors: | Casey W. Williamson Anthony Paravati Majid Ghassemi Kristine Lethert Patricia Hua Patricia Hartman Parag Sanghvi |
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| Affiliation: | aDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, Calif., USA;bDepartment of Pathology, Kaiser Permanente, San Diego, Calif., USA;cDepartment of Hematology-Oncology, Kaiser Permanente, San Diego, Calif., USA |
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| Abstract: | Multiple primary malignancies (MPMs) are present when a patient is diagnosed with more than one primary malignancy and when each tumor is histologically unrelated to the others. MPMs are considered synchronous when they present within 6 months of one another. Here, we report the case of a 57-year-old woman with a past medical history significant for melanoma in 1988, who presented in 2014 with 5 distinct tumors within 4 months: malignant melanoma of the right popliteal fossa, invasive lobular breast carcinoma, diffuse large B cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and a giant cell tumor of tendon sheath/pigmented villonodular synovitis. We discuss her treatment and also present a brief review of the literature. The incidence of MPMs appears to be on the rise, which demands an interdisciplinary, multimodal, and personalized approach to care.Key Words: Multiple malignancies, Melanoma, Breast cancer, Lymphoma, Giant cell tumor |
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