The effect of lymphokines on the development of delayed hypersensitivity to an unrelated antigen |
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| Authors: | J Krej
í J Pekrek J &#x;vejcar and J Johanovský |
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| Institution: | J. Krejčí, J. Pekárek, J. Švejcar, and J. Johanovský |
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| Abstract: | The development of delayed hypersensitivity to sheep red cells in rabbits was assessed by measuring the inhibition of migration of cells from spleen fragments in the presence of sheep red cell antigen. Supernatants containing migration inhibition factor were prepared by incubating lymph node cells from rabbits immunized with Freund's complete adjuvant with PPD. Sheep red cells injected together with these supernatants intravenously gave rise to delayed hypersensitivity. In contrast the injection of sheep red cells alone or with control supernatants did not give rise to delayed hypersensitivity. |
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