血小板活化与肺原性心脏病的关系

目的 探讨血小板活化与肺原性心脏病（肺心病）的关系。方法 应用单克隆抗体法并在流式细胞仪上对血小板活化分子标志物CD62P、P10进行检测，同时跟踪检测病人血气和呼吸功能，以了解它们之间关系。结果 肺心病病人血小板异常活化，与对照组比较差异有显著性（P＜0．01）；血小板活化程度与PaO2、呼吸功能呈显著负相关。结论 血小板异常活化能加重肺心病病情，应用抑制血小板活化药物和适当抗凝可能有利于肺心病疗效的提高。

Relationship between Platelet Activation and Cor Pulmonale

Objective\ To investigate the relationship between the platelet activation and cor pulmonale.\ Methods\ Plasma concentration of platelet\|activating markers CD\-\{62P\} and P\-\{10\} on platelet surface were assayed using ELISA and FCM, patient's blood gas and pulmonary functions were also analysed.\ Results\ The patients of cor pulmonale had abnormal platelet activation, as compared with that in control, with remarkable difference(P<0.01).\ The level of plateler activation was negatively related with that of PaO\-2 and pulmonary functions significantly.\ Conclusion\ There is an abnormal platelet activation in cor pulmonale, especially when the condition worsened.\ It is valuable to treat cor pulmonale using platelet activation controlling drug and coagulant.