热淋清颗粒对肾盂肾炎模型大鼠的药效学研究

目的:观察热淋清颗粒对感染性肾盂肾炎大鼠模型的影响。方法:大鼠肾实质内接种大肠埃希菌ATCC-25922,制做大鼠细菌性肾盂肾炎模型,分为热淋清52.32,26.16 g.kg^-1组,氟哌酸(0.03 g.kg^-1)组及模型组,同时设正常对照组(未感染细菌者),观察其对尿液中的白细胞数、糖、尿蛋白、隐血、酮体、胆红质以及尿胆原的影响。结果:大鼠灌服热淋清颗粒(头花蓼浸膏粉)6.0 g.kg^-1(折合生药量为52.32 g.kg^-1)与模型对照组比,给药后能显著减少尿液中的白细胞数量及隐血,但对尿液其他生化指标没有明显影响。结论:热淋清颗粒对大鼠细菌感染性肾盂肾炎,具有显著减少尿液中白细胞数量及隐血的作用

Pharmacodynamic study of Relinqing granules on bacterial pyelonephritis model in rats

Objective: To observe the effects of Relinqing granules(powder of Polygonum capitatum extract) on the bacterial pyelonephritis model in rats.Method: The rat bacterial pyelonephritis model was induced by injecting the escherichia coli ATCC-25922 into kidney parenchyma.The rats were divided ramdamly into Relinqing groups(52.32,26.16 g·kg^-1),norflorin group(0.03 g·kg^-1),model group and normal control group,and were given experimental drugs by gastrogavage.The contents of leucocytes (WBC),occult bloo(BLD),glucose(GLU),protein(PRO),ketones,bilirubin and urobilinagen in urine were determined.Result: As compared with the model group,Relinqing granules 6.0 g·kg^-1(crude drug 52.32 g·kg^-1) could decrease significantly the contents of WBC and BLD in urine and,however,had no markedly effects on the other biochemical parameters of urine.Conclusion: Relinqqing granule has significant effects of decreasing urine WBC and BLD on the bacterial pyolonephritis in rats.