小剂量芬太尼复合丙泊酚静脉麻醉用于无痛胃镜检查的临床研究

目的观察小剂量芬太尼复合丙泊酚静脉麻醉用于无痛胃镜检查的临床效果。方法 120例行胃镜检查的患者随机分为观察组和对照组各60例,对照组给予丙泊酚静脉麻醉,治疗组给予小剂量芬太尼复合丙泊酚静脉麻醉。观察2组患者在检查过程中平均动脉压（MBP）、心率（HR）和血氧饱和度（SpO2）变化情况,观察并记录神志恢复时间及不良反应,比较2组麻醉效果。结果观察组麻醉效果优级率为80.0%高于对照组的41.7%,差异有统计学意义（P〈0.05）。观察组意识恢复时间短于对照组,差异有统计学意义（P〈0.05）。2组检查时HR均降低,检查后MBP降低,与检查前比较差异均有统计学意义（P〈0.05）。2组生命体征各观察指标比较差异无统计学意义（P〉0.05）。结论小剂量芬太尼复合丙泊酚静脉麻醉用于无痛胃镜检查镇静效果好,清醒快,恢复快,不良反应少。

Clinical study on small dose of fentanyl combined with propofol intravenous anesthesia for painless gastroscopy

Objective To observe clinical effect of small dose of fentanyl combined with propofol intravenous anesthesia for painless gastroscopy. Methods 120 cases patients were randomly divided into observation group and control group,60 cases of each. The control group received intravenous propofol anesthesia,the treatment group was given small doses of fentanyl and propofol anesthesia. Observed mean arterial blood pressure（ MBP） ,heart rate（ HR） and oxygen saturation（ SpO2 ） of two groups in the examination process,recorded consciousness recovery time and adverse reactions,compared anesthesia effect of the two groups. Results Anesthetic priority level rate of the observation group（ 80. 0% ） was higher than that of control group （ 41. 7%） ,the difference was statistically significant（ P 0. 05）. Consciousness recovery time of observation group was shorter than the control group,the difference was statistically significant（ P 0. 05）. Compared with the pre-inspection,HR decreased at examination time both for the two group,and MBP decreased after inspection（ P 0. 05）. There were no significant difference of vital signs between the two groups（ P 0. 05）. Conclusion Small dose of fentanyl combined with propofol intravenous anesthesia for painless gastroscopy is sedative effect,sober fast,rapid recovery and fewer adverse reactions.