床旁单泵血液灌流治疗重度有机磷中毒的临床研究

目的:研究床旁单泵血液灌流治疗重度急性有机磷农药中毒(AOPP)的效果。方法:将90例重度急性有机磷农药中毒者随机分为治疗组45例和对照组45例,2组均常规洗胃、导泻、输液及阿托品、氯磷定治疗。治疗组行床旁单泵血液灌流(HP)。结果:治疗组和对照组比较,患者昏迷至清醒时间、阿托品化时间、血清胆碱酯酶活力恢复时间、住院时间明显缩短(P0.01),阿托品总量明显降低(P0.01),病死率降低(P0.05)。结论:HP能迅速清除体内毒物,治疗重度有机磷中毒疗效良好。

Clinical analysis of bedside hemoperfusion in treatment severe organophosphorus pesticide poisoning

Objective：To study the clinical effects of bedside hemoperfusion therapy in treatment of acute severe organophosphorus pesticide poisoning（AOPP）.Method：90 patients with severe AOPP were randomly divided into the treatment group（45 cases）and the control group（45 cases）.Patients in both groups were given conventional treatment including gastrolavage,purgation,fluid infusion,atropine and pralidoxime chloride.Patients in treatment group were given additional hemoperfusion therapy（HP）.Result：In comparison with the control group,patients in the treatment group needed shorter time for atropinization,shorter time for serum cholinesterase activity to recovery,shorter time for waking from the coma and shorter time for hospitalization（P0.01）.Moreover,Total dose of atropine applied in the treatment group were lower（P0.01）and the mortality were lower in this gruop（P0.05）.Conclusion：Conclusion：Hemoperfusion can clear organophosphorus pesticide rapidly in the body,which can treatment acute organophosphorus pesticide poisoning effectively.