维生素C透析液对继发性甲状旁腺功能亢进的影响

目的了解维生素C透析液对维持性血液透析患者继发性甲状旁腺功能亢进的影响。方法选择在郑州大学第一附属医院血液净化中心长期透析的患者82例,随机分成两组,分别使用常规透析液(A组40例)和含维生素C透析液(B组42例)进行血液透析,周期为3个月,试验开始前及3个月后分别于透析前抽血化验血清全段甲状旁腺素(intact parathyroid hormone,iPTH)、钙、磷、钙磷乘积、碱性磷酸酶(alkaline phosphatase,ALP)、维生素C水平。结果 A组试验3个月后血清iPTH、ALP轻度升高,钙、磷、钙磷乘积无明显变化,差异无统计学意义(P0.05),维生素C降低,差异有统计学意义(t=-2.35,P0.05);B组试验3个月后血清iPTH、ALP明显降低,差异有统计学意义(P0.05),钙、磷、钙磷乘积无明显变化,维生素C轻度升高,差异无统计学意义(t=0.14,P0.05)。结论常规透析使大量维生素C丢失;维生素C可以降低血清iPTH、ALP,预防继发性甲状旁腺功能亢进。

The effect of dialysate containing vitamin C on secondary hyperparathyroidism

Objective To comprehend the effect of vitamin C-containing dialysate on secondary hyperpar-athyroidism in patients on maintenance hemodialysis (MHD). Methods Eighty-two stable MHD patients were enrolled in this study,and they were randomly assigned into group A or group B. Patients in group A (40 cases) used regular dialysate,and those in group B (42 cases) used vitamin C-containing dialysate for MHD for 3 months. Serum intact parathyroid hormone (iPTH),Ca,P,Ca x P product,alkaline phosphatase (ALP) and vit...