Visual responses related to food discrimination in monkey lateral hypothalamus during operant feeding behavior |
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| Authors: | Masaji Fukuda Taketoshi Ono Hitoo Nishino Kazuo Sasaki |
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| Affiliation: | 1. Brain and Cognition, KU Leuven, 3000 Leuven, Belgium;2. Department of Psychology, Durham University, Durham, United Kingdom;3. Department of Psychology, Stirling University, Scotland, United Kingdom;1. Proaction Laboratory, Faculty of Psychology and Education Sciences, University of Coimbra, Portugal;2. Faculty of Psychology and Education Sciences, University of Coimbra, Portugal;3. Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA;4. Center for Visual Science, University of Rochester, Rochester, NY, USA;5. Department of Neurosurgery, University of Rochester, Rochester, NY, USA;6. Department of Neurology, University of Rochester, Rochester, NY, USA;1. Human Cortical Physiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA;2. Division of Psychology, Department of Life Sciences, Brunel University, Uxbridge UB8 3PH, United Kingdom;3. Laboratory for Social and Neural Systems Research (SNS Lab), University of Zurich, Rämistr. 100, CH-8091 Zurich, Switzerland;4. Wellcome Trust Centre for Neuroimaging, University College London, London WC1N 3BG, United Kingdom;5. Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;6. Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom;7. Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA;8. Department of Psychology, Royal Holloway, University of London, Egham Hill, Egham, Surrey TW20 0EX, United Kingdom;1. Department of Psychology, Emory University, Atlanta, GA, United States;2. Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, United States;3. Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA;1. Center for Mind/Brain Sciences, University of Trento, Rovereto, Italy;2. Laboratory of Biological Psychology, University of Leuven, Leuven, Belgium;3. Department of Psychology, Harvard University, Cambridge, MA, USA;4. Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands |
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| Abstract: | Single neuron activity was recorded from monkey lateral hypothalamic area (LHA) to relate neuronal events to food discrimination and initiation of procurement movement in operant bar press feeding behavior. Of 429 neurons tested, 68 (16%) responded during visual phase. Of these, 30 (7%) responded selectively to the sight of food or non-food associated with a juice reward, but not to the sight of meaningless non-food or food associated with aversive saline. Neuronal activity related to discrimination was readily influenced by extinction, reversal or satiation. The strength of visual responses was correlated with latency of bar press initiation and speed of bar pressing, but was not related directly to bar press movement. These suggest that the LHA is deeply involved in discrimination of reinforcement or non-reinforcement, and might be associated with higher functions to regulate internal states such as physiological need to get food during operant feeding behavior. |
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| Keywords: | single neuron activity visual response learning feeding behavior lateral hypothalamic area monkey |
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