Sequenc spectra of spontaneous lacZ gene mutations in trransgenic mouse somatic and germline tissues |
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| Authors: | Douglas, George R. Gingerich, John D. Gossen, Jan A. Barlett, Sheryl A. |
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| Affiliation: | 1Mutagensis Sectiion, Environmental Health Directorate, Health Canada Ottawa Ontario K1A OL2, Canada 2Ingeny b. v., PO Box 685, 2300 AR Leiden, The Netherlands and Harvard Medical School, Beth Israel Hospital 730 Brooklike Road Boston MA 02215 USA 3Biostatics and Computer Applicatons Divisin, Environmental Health Diretorate Health Canada, Ottawa K1A OL2, Canada |
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| Abstract: | As a critical step in determining whether transgenic mouse genemutation systems are suitable models for the detection and quantificationof induced gene mutations in vivo, spontaneous mutant frequenciesand mutation spectra have been characterized for liver, bonemarrow, and male germ cells of the lacZ transgenic mouse strain40.6. The lacZ transgene is carried on a recombinant bacteriophage |
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