Pertussis vaccine oedema: An experimental model for the action of penicillamine-like drugs |
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| Authors: | E. Arrigoni-Martelli E. Bramm E. C. Huskisson D. A. Willoughby P. A. Dieppe |
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| Affiliation: | (1) Department of Pharmacology, Leo Pharmaceutical Products, DK-2750 Ballerup, Denmark;(2) Department of Rheumatology and Experimental Pathology, St. Bartholomew's Hospital, EC.1 London |
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| Abstract: | A delayed hypersensitivity response was induced in the rat paw using pertussis vaccine. Oedema was measured after the challenging injection.d-Penicillamine and levamisole enhanced the response, while indomethacin suppressed it. This model is useful to distinguish the effects of antiinflammatory drugs from those liked-penicillamine which have a specific activity in rheumatoid arthritis. |
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