Effect of klofenil on the hemodynamic and autonomic nervous system functions in patients with hypertensive disease

The degree of hemodynamic and vegetative changes is determined to a great extent by the time of clopheline intake. The maximal changes in the sympathetic activity at rest and during active orthostasis were revealed in the morning hours and in the second half of the day, the minimal ones--in the afternoon hours. The hemodynamic changes were most pronounced at 12 o'clock and minimal at 7 o'clock.