Anovulatory effect of a LHRH antagonist in women |
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Authors: | Arturo Zarate Elias S Canales Irma Sthory David H Coy Ana Maria Comaru-Schally Andrew V Schally |
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Institution: | 1. Department of Endocrinology, Hospital Gineco-Obstetricia, Instituto Mexicano Seguro Social, Mexico City, D.F., Mexico;2. Veterans Administration Medical Center and Tulane University School of Medicine, New Orleans, LA, USA |
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Abstract: | The antagonistic analog of LHRH, NAc-D-p-C1-Phe1,2, D-Trp3, D-Phe6, D-Ala10-LHRH was administered intramuscularly in a dose of 2 mg to ten normally ovulating women on day 12 of the menstrual cycle. Ovulation was inhibited in six patients, and two more presented an insufficient corpus luteum. No pregnancies were recorded in this series. In those patients who did not ovulate, it was demonstrated that the LHRH analog abolished the midcycle surge of both LH and FSH. Luteolysis evidenced by the rapid decline in progesterone levels was present in 2 cases. Bleeding pattern showed a tendency to delayed menses. The morphological findings in endometrial biopsies of 6 women exhibited mild proliferation. Further research along these lines is necessary for appraisal of this approach to birth control. |
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Keywords: | Reprint requests: Dr A Zarate Dept Endocrinology IMSS Ap Postal 99-073 Mexico 20 DF |
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