针刺联合紫杉醇对Lewis肺癌小鼠一般状态及抑瘤率影响的实验研究

目的通过采用针剌联合抗癌新药紫杉醇对LewiS肺癌小鼠进行治疗，探讨针药结合对肿瘤的治疗效应，验证针药并举理论及协同增效作用。方法复制小鼠LewiS肺癌模型，分别采用针刺、药物及针药结合法对其进行治疗，观察小鼠的生存状态、肿瘤体积的动态变化、瘤重及抑瘤率。结果针刺、紫杉醇、针刺联合紫杉醇均能抑制肿瘤生长，具有良好的抑瘤作用，针剌联合紫杉醇抑瘤效果更加显著。结论针刺联合紫杉醇治疗有更显著的抗肿瘤作用，并能改善实验动物的生存状态，针药结合对LewiS肺癌小鼠的治疗效果明显优于单一疗法。

Experimental Study on Effect of Acupuncture Associating with TAX on General State and Tumour-curbed Rats of Lewis Lung Cancer Mice

Objective Adopting acupuncture associating with TAX to treat mice with Lewis lung cancer, to investigate the anti-cancer effect and its mechanism, and affirm their cooperating effect. Methods Lewis lung cancer model in mice was established and treated with acupuncture, medication and the combination of acupuncture and medication separately. The growth state of the mice, change and growth curve of tumour, change of tumour-weight and tumour-curbed rate were observed. Results Acupuncture, TAX and the combination of acupuncture and TAX all can curb the tumour, and the combination was the best. Conclusion The combination of acupuncture and TAX has a marked anti-cancer effect and can improve growth state of the mice. The effect of combining method is better than single therapy.