| 冬虫夏草多糖脂质体口服液制备工艺优选 |
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| 引用本文： | 冯祚臻,官东秀,张晓婷. 冬虫夏草多糖脂质体口服液制备工艺优选[J]. 中国药业, 2005, 14(8): 50-51 |
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| 作者姓名： | 冯祚臻 官东秀 张晓婷 |
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| 作者单位： | 1. 广西玉林市红十字会医院,广西,玉林,537000
2. 广州星群(药业)有限公司,广东,广州,510288 |
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| 摘 要： | 目的:优选冬虫夏草多糖脂质体口服液的制备工艺.方法:采用正交试验法考察提取时间、次数、加水体积和超声乳化时间4个因素,以冬虫夏草多糖含量和包封率为评价指标.结果:最佳制备工艺为A3B3C3D2,即加药材8倍量的水提取3次,每次3 h,超声乳化时间为15 min.结论:制剂稳定,测定方法重现性好.
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| 关 键 词： | 冬虫夏草多糖脂质体口服液 正交试验法 制备工艺 |
| 文章编号： | 1006-4931（2005）08-0050-02 |
| 收稿时间： | 2004-10-25 |
| 修稿时间： | 2004-12-20 |
Study on the Preparation Process of the Cordyceps Sinensis Sacc Polysaccharide Liposomal Oral Liquid by Orthogonal Design |
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| Feng Zuozhen,Guan Dongxiu,Zhang Xiaoting. Study on the Preparation Process of the Cordyceps Sinensis Sacc Polysaccharide Liposomal Oral Liquid by Orthogonal Design[J]. China Pharmaceuticals, 2005, 14(8): 50-51 |
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| Authors: | Feng Zuozhen Guan Dongxiu Zhang Xiaoting |
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| Abstract: | Objective:To optimize the preparation procedure for the cordyceps s in ensis Sacc polysaccharide liposomal oral liquid.Methods:The orthogonal design wa s used to study the four factors,including extraction time,extraction times,the amount of water added and emulsifiable time by ultrasound,taking the content of cordyceps sinensis Sacc polysaccharide and the entrapment efficiency as markers. Results:The optimum preparation process obtained was A3B3C3D3.Its emulsifiable t ime by ultrasound was 15 min.It was extracted by water 3 times,3 h for each time ,8 times in all the water was much as the midicine material.Conclusion:The prepa ration is stable.The method is simple,sensitive,accurate and reproducible. |
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| Keywords: | cordyceps sinensis Sacc polysaccharide liposomal oral liquid orthogo nal design preparative procedure |
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