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Prevalence of non-alcoholic steatohepatitis (NASH) among biopsied cases of a urban hospital in Japan: significance of measurement of serum ferritin in the detection of NASH]
Authors:Yosiaki Yajima  Nobutaka Takahashi  Atsusi Miyazaki  Ryosuke Kikuchi  Keisuke Kakisaka  Keisuke Oikawa  Kazuhiko Sugawara  Yoshiki Eda  Hiroshi Naganuma  Masamitsu Unagami
Institution:Department of Gastroenterology, Sendai City Hospital.
Abstract:From April 1989 to December 2004, we performed liver biopsy on 475 patients and obtained biopsy proven 35 cases of non-alcoholic fatty liver. Among them, 18 cases were diagnosed as non-alcoholic steatohepatitis (NASH). During the last three years, we have tried to detect NASH using ultrasonography and elevated value of serum ferritin (> 300 ng/ml). All of the eligible 7 cases biopsied during the course were diagnosed as NASH. In these 7 cases, ALT levels improved after the body weight loss accompanied by the parallel decrease of serum ferritin levels. Measurement of serum ferritin is useful in the detection of NASH but the normal value of ferritin cannot rule out the possibility of NASH.
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