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| 低浓度环氧丙烷的细胞遗传学效应研究 | |
| 引用本文： | 李明,陈彦文,徐敏秋,李梦燕,王立言,张吉,李玉杰,于秀兰,刘积善. 低浓度环氧丙烷的细胞遗传学效应研究[J]. 工业卫生与职业病, 2000, 26(4): 204-206 |
| 作者姓名： | 李明 陈彦文 徐敏秋 李梦燕 王立言 张吉 李玉杰 于秀兰 刘积善 |
| 作者单位： | 1. 锦化化工公司职业病防治所,葫芦岛市,125001 2. 葫芦岛市职业病防治所 3. 辽宁省劳动卫生职业病防治所 |
| 摘 要： | 为探讨低浓度环氧丙烷的细胞跗学效应，对４６名环氧丙烷作业工人和７４名对照工人外周血淋巴细胞染色体畸变、微核、姐妹染色单体交换进行了检测分析。结果表明，环氧丙烷接触组工人外周因细胞姐妹染色单体交换率显著高于对照组，而染色体畸变率和微核率两组间均无显著性差异，提示低浓度环氧丙烷具有细胞遗传学毒性，可导致ＤＮＡ损伤。 |
| 关 键 词： | 环丙烷 染色体畸变 微核 SCE 细胞遗传学效应 |
Investigation on Cytogenetic Effects of Low Level Propylene Oxide Exposure |
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| Li Ming et al. Investigation on Cytogenetic Effects of Low Level Propylene Oxide Exposure[J]. Industrial Health and Occupational Diseases, 2000, 26(4): 204-206 | |
| Authors: | Li Ming et al |
| Abstract: | In order to explore the cytogenetic effects of low level propylene oxide exposure,chromosome aberration(CA),micronucleus(MN)and sister chromatid exchange(SCE) in peripherial blood lymphocytes of 46 workers occupationally exposed to propylene oxide and 74 healthy workers as normal control were detected.The results showed that the frequency of SCE in the exposed workers was significantly higher than that of control.Frequencies of CA and MN had no obvious difference between the exposed group and the control group.It indicated that propylene oxide might have cytogenotoxicity and induce DNA damage. |
| Keywords: | Propylene oxide Chromosome aberration(CA) Micronucleus(MN) Sister chromatid exchange(SCE) |
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