HER2在乳腺浸润性导管癌中的表达及意义

目的:观察人类表皮生长因子2(简称HER2)在乳腺浸润性导管癌组织中的表达,探讨HER2表达与其淋巴结转移的关系及意义。方法:采用免疫组织化学技术检测15例正常乳腺组织和60例原发性乳腺浸润性导管癌中HER2基因的表达。结果:乳腺浸润性导管癌组织HER2表达总阳性率为67%,有淋巴结转移者其阳性率(65.22%)明显高于无淋巴结转移者(35.14%)(P<0.05);uPAR阳性的癌组织中HER2表达阳性率显著升高[(84.21±36.36)%,P<0.05],uPAR与HER2之间的表达高度相关。结论:HER2蛋白在乳腺浸润性导管癌中高度表达,且其过度表达与乳腺浸润性导管癌淋巴结转移有关。

Clinical Significance and Overexpression of HER2 in Infiltrating Ductal Breast Cancer

Objective:To investigate the clinical Significance and overexpression of HER2 in Infiltrating ductal breast cancer.Methods:Immunohistochemical technique was used to determine the expressions of HER2 in 15 cases of normal breast and 60 cases of infiltrating ductal breast cancer.Results:The positive rate of HER2 protein expression in breast carcinoma was 67.00%,of which the positive rate 65.22% with lymphatic metastasis was significantly higher than that without lymphatic metastasis 35.14%(P<0.05).In the uPAR expressing breast cancers,the positive rate of HER2 expression(84.21%) was higher than that in the breast cancers without uPAR expression.There was obvious correlation between uPAR and HER2.Conclusion:Overexpressions of HER2 protein occurre in primary breast carcinoma and have a close correlation with lymphatic metastasis.Expressions of HER-2 and uPAR in infiltrating ductal breast carcinoma predicte gene status of patients and provided the clinical targets for predicting lymphatic metastasis of breast carcinorma.