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Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia |
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| Authors: | Said Aboud Gernard Msamanga Lei Wang Usha Sharma Taha E. Taha Wafaie W. Fawzi |
| Affiliation: | a Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania b Department of Community Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania c Pediatric, Adolescent, and Maternal AIDS Branch, NICHD, NIH, DHHS, Bethesda, MD, USA d Statistical Center for HIV/AIDS Research and Prevention (SCHARP), Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA, USA e Prevention Sciences Program, NIAID, NIH, Bethesda, MD, USA f UNC Project, Lilongwe, Malawi g Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA h Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA, USA i Department of Nutrition, Harvard School of Public Health, Boston, MA, USA |
| Abstract: | ObjectiveWe assessed the effect of prenatal and peripartum antibiotics on maternal morbidity and mortality among HIV-infected and uninfected women.MethodsA multicenter trial was conducted at clinical sites in 4 Sub-Saharan African cities: Blantyre and Lilongwe, Malawi; Dar es Salaam, Tanzania; and Lusaka, Zambia. A total of 1558 HIV-infected and 271 uninfected pregnant women who were eligible to receive both the prenatal and peripartum antibiotic/placebo regimens were enrolled. Pregnant women were interviewed at 20-24 weeks of gestation and a physical examination was performed. Women were randomized to receive either antibiotics or placebo. At the 26-30 week visit, participants were given antibiotics or placebo to be taken every 4 hours beginning at the onset of labor and continuing after delivery 3 times a day until a 1-week course was completed. Logistic regression and Cox proportional hazards models were used.ResultsThere were no significant differences between the antibiotic and placebo groups for medical conditions, obstetric complications, physical examination findings, puerperal sepsis, and death in either the HIV-infected or the uninfected cohort.ConclusionAdministration of study antibiotics during pregnancy had no effect on maternal morbidity and mortality among HIV-infected and uninfected pregnant women. |
| Keywords: | Antibiotics HIV Maternal morbidity Maternal mortality Pregnancy |
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