临床量表对肺栓塞诊断价值的研究

目的 评价和比较Wells量表与Geneva量表对肺栓塞的诊断价值.方法 回顾性分析1995年1月至2009年1月诊治的可疑肺栓塞958例患者的临床资料,分别以Wells量表和Geneva量表进行肺栓寨的可能性评估,并与最终影像学检查确诊的诊断结果进行分析比较.结果 以影像学检查结果为标准,共有347例患者确诊为肺栓塞.两个量表诊断肺栓塞的敏感度、特异度、阳性预测值和阴性预测值：Wells量表分别为82.4%、58.1%、52.8%和85.3%;Geneva量表分别为88.8%、55.3%、53.1%和89.7%.诊断肺栓塞的阳性似然比、阴性似然比、Youden指数和一致性系数：WeBs 量表为1.97、0.30、0.41和0.21;Geneva量表分别为1.99、0.20、0.44和0.25.Geneva量表的ROC曲线下面积为0.79,大于WeHs量表的0.73,两者差异有统计学意义（Z=2.25,P＜0.05）.Geneva量表与Wells量表诊断肺栓寨的敏感度和特异度比较差异有统计学意义（χ^2值分别为7.12和6.84,均P＜0.05）.结论 虽然临床量表与影像学确诊检查方法的准确性尚有很大差距,但均可用于各级医院Geneva量表与Wells量表的筛查,具有一定的辅助诊断价值,有利于节省不必要的医疗开支;与WeHs量表相比,Geneva量表更加实用、准确,值得临床推广.

An study on significance of clinical scales in diagnosis for pulmonary embolism

Objective To assess diagnostic value of Wells and Geneva seales in patients with suspected pulmonary embolism(PE).Methods Clinical data of 958 consecutive cases of suspected PE admitted to Shanghai Pulmonary Hospital form January 1,1995 to January 1,2009,were analyzed retrospectively,and all patients were assessed with Wells and Geneva scales,respectively for likelihood of PE,as compared to those diagnosed by lung imaging Results Three hundred and forty-seven patients with PE were diagnosed with lung imaging as gold standard,sensitivity,specificity,and positive and negative predictive values for Wells scale and Geneva scale in diagnosis for PE were 82.4%,58.1%,52.8%and 85.3%.and 88.8%,55.3%,53.1%and 89.7%,respectively,with positive and negative likelihood ratios.Youden index and crude agreement of 1.97,0.30,0.41 and 0.21,and 1.99,0.20,0.44 and 0.25.respectively.Area under the receiver operating characteristic(ROC) curve of Geneva scale(0.79)was significantly more than that of Wells scale(0.73)(Z=2.25,P＜0.05).As compared to Wells scale,sensitivity and specificity for Geneva scale in diagnosis for PE was significantly higher(χ2=7.12 and 6.84,respectively,P＜0.05).Conclusions Although there is a considerable gap in accuracy between clinical scales and lung imaging in diagnosis for PE.both Wells and Geneva scales can be used in clinical screening for PE to save unnecessary cost.however,Geneva scale is more practical and accurate than Wells scale,worthwhile to be popularized clinically.