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| Primary malignant melanoma of the liver： A case report | |
| 引用本文： | Gong L,Li YH,Zhao JY,Wang XX,Zhu SJ,Zhang W. Primary malignant melanoma of the liver： A case report[J]. World journal of gastroenterology : WJG, 2008, 14(31): 4968-4971. DOI: 10.3748/wjg.14.4923 |
| 作者姓名： | Gong L Li YH Zhao JY Wang XX Zhu SJ Zhang W |
| 作者单位： | [1]Department of Pathology, Tangdu Hospital, the Fourth Military Medical University, Xi＇an 710038, Shaanxi Province, China [2]Department of Gynaecology and Obstetrics, Tangdu Hospital, the Fourth Military Medical University, Xi＇an 710038, Shaanxi Province, China [3]Department of Gastroenterology, Tangdu Hospital, the Fourth Military Medical University, Xi＇an 710038, Shaanxi Province, China |
| 基金项目： | ACKNOWLEDGMENTS The authors thank all the patients and their families for participating in this research. |
| 摘 要： | Primary malignant melanoma of the liver is an exceedingly rare tumor. Only 12 cases have been reported in the worldwide literature. We present a case of isolated malignant melanoma of the liver occurring in a 36-year-old Chinese male patient. Comprehensive dermatologic and ophthalmologic examinations revealed no evidence of a cutaneous or ocular primary lesion. Other lesions in brain, respiratory tract, lung, gastrointestinal tract and anus, were not demonstrated by serial position emission tomography （PET）. Microscopic examination of the resected specimen revealed a malignant melanoma, which was confirmed by immunohistochemical staining for HMB-45, S-100 protein, melanoma-pan and vimentin. Moreover, electron microscopy demonstrated melanosomes in tumor cell cytoplasm. Our case shows that primary malignant melanoma may occur in the liver and should be considered when the histopathological appearance is not typical for other hepatic neoplasm. |
| 关 键 词： | 黑色素瘤 肝疾病 诊断方法 免疫组织化学 |
| 收稿时间： | 2008-05-18 |
Primary malignant melanoma of the liver: a case report |
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| Gong Li,Li Yan-Hong,Zhao Jian-Ye,Wang Xu-Xia,Zhu Shao-Jun,Zhang Wei. Primary malignant melanoma of the liver: a case report[J]. World journal of gastroenterology : WJG, 2008, 14(31): 4968-4971. DOI: 10.3748/wjg.14.4923 | |
| Authors: | Gong Li Li Yan-Hong Zhao Jian-Ye Wang Xu-Xia Zhu Shao-Jun Zhang Wei |
| Affiliation: | 1. Department of Pathology,Tangdu Hospital,the Fourth Military Medical University,Xi'an 710038,Shaanxi Province,China 2. Department of Gynaecology and Obstetrics,Tangdu Hospital.the Fourth Military Medical University,Xi'an 710038,Shaanxi Province,China 3. Department of Gastroenterology,Tangdu Hospital,the Fourth Military Medical University,Xi'an 710038,Shaanxi Province,China |
| Abstract: | Primary malignant melanoma of the liver is an exceedingly rare tumor.Only 12 cases have been reported in the worldwide lirerature.We present a case of isolated malignant melanoma of the liver occurring in a 36-year-old Chinese male patient.Comprehensive dermatologic and ophthalmologic examinations revealed no evidence of a cutaneous or ocular primary lesion.Other lesions in brain,respiratory tract,lung,gastrointestinal tract and anus,were not demonstrated by serial position emission tomography(PET).Microscopic examination of the resected specimen revealed a malignant melanoma,which was confirmed by immunohistochemical staining for HMB-45,S-100 protein,melanoma-pan and vimentin.Moreover,electron microscopy demonstrated melanosomes in tumor cell cytoplasm.Our case shows that primary malignant melanoma may occur in the liver and should be considered when the histopathological appearance is not typical for other hepatic neoplasm. |
| Keywords: | Primary malignant melanoma Liver Diagnosis Histopathology Immunohistochemistry |
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