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Central pontine myelinolysis following ‘slow’ correction of hyponatremia |
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| Authors: | Sunil Pradhan Ratan Jha Madhurendra N. Singh Sandeep Gupta Rajendra V. Phadke Vijay Kher |
| Affiliation: | aDepartment of Neurology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Lucknow 226 014, India bDepartment of Nephrology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Lucknow 226 014, India cDepartment of Radiology, Sanjay Gandhi Post-graduate Institute of Medical Sciences, Lucknow 226 014, India |
| Abstract: | Two patients with central pontine myelinolysis are described for the peculiar mode of development. Both patients were in chronic renal failure and admitted in a stuporous state due to hyponatremia. Both developed central pontine myelinolysis during the hospital stay following slow and judicious correction of hyponatremia. The role of chronicity of hyponatremia prior to its correction, in the genesis of central pontine myelinolysis, particularly in the patients who have chronic debilitating illness, septicemia or malnutrition, is highlighted. |
| Keywords: | Central pontine myelinolysis Hyponatremia Myelinolysis Chronic renal disease |
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