2006～2009年武汉同济医院血液科病房主要病原菌耐药性变迁

目的了解武汉同济医院血液科病房2006～2009年主要病原菌耐药性变迁。方法将分离的病原菌采用K-B法进行药敏试验，应用WHONET5．4软件进行数据分析。结果前3位病原菌为凝固酶阴性葡萄球菌、大肠埃希菌和铜绿假单胞菌。凝固酶阴性葡萄球菌和大肠埃希菌耐药严重。耐甲氧西林的凝固酶阴性葡萄球菌和超广谱13内酰胺酶（ESBLs）阳性大肠埃希菌检出率在2006～2008年间呈逐年上升趋势，2009年稍有下降，铜绿假单胞菌2007年后对头孢哌酮／舒巴坦、美罗培南、哌拉西林／他唑巴坦及左旋氧氟沙星的耐药率呈下降趋势。结论凝固酶阴性葡萄球菌、大肠埃希菌和铜绿假单胞菌是血液科病房主要致病菌；耐甲氧西林的凝固酶阴性葡萄球菌和ESBLs（＋）大肠埃希菌耐药2006—2008年间呈逐年上升趋势，2009年稍有下降；铜绿假单胞菌2007年后对常用抗生素耐药率呈下降趋势。

Antibiotic resistance vicissitudes of major infection pathogens in hematology ward wuhan Tongji hospital from 2006 to 2009

Objective To investigate the antibiotic resistance vicissitudes of major infection pathogens in hematology ward Wuhan Tongji Hospital for recent 4 years. Methods Bacterial susceptibility test was carried out using K-B method. Data were analyzed by WHONET 5.4 software. Results The top there pathogens were Coagulase negative Staphylococcus, Escheriehia eo]i and Pseudomonas aeruginosa. Coagulase negative Staphylococcus and Escheriehia coli showed high resistance to antibiotics. The detection rate of MRCNS and ESBLs（ ＋ ） Escherichia coil showed a tendency to increase from 2006-2008, but showed a tendency to decrease in 2009. The resistance to antibiotics of Pseudomonas aeruginosa showed a declined tendency to eepoperazon/sulbactam, meropenem, piperaeillin/tazohactam and levofloxacin after 2007. Conclusiotis The most pathogens were Coagulase negative Staphylococcus, Escheriehia coli and Pseudomonas aeruginosa in hematology ward. The resistance to antibiotics of MRCNS and ESBLs （ ＋ ） Escherichia coli showed a tendency to increase from 2006-2008, but a tendency to decrease in 2009. Pseudomonas aeruginosa showed a declined resistance tendency to routine antibiotics after 2007.