| 小遍在蛋白质样修饰物化修饰及其在非综合征性唇腭裂发病中的意义 |
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| 引用本文： | 廖礼姝,蒙田,郑谦,石冰. 小遍在蛋白质样修饰物化修饰及其在非综合征性唇腭裂发病中的意义[J]. 国际口腔医学杂志, 2009, 36(1) |
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| 作者姓名： | 廖礼姝 蒙田 郑谦 石冰 |
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| 作者单位： | 四川大学华西口腔医院唇腭裂外科,四川,成都,610041;四川大学华西口腔医院唇腭裂外科,四川,成都,610041;四川大学华西口腔医院唇腭裂外科,四川,成都,610041;四川大学华西口腔医院唇腭裂外科,四川,成都,610041 |
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| 摘 要： | 蛋白组学研究发现,转录后蛋白质的小遍在蛋白质样修饰物(SUMO)化修饰在生物体生命活动中发挥着广泛的生理作用.SUMO家族中的SUMO-1广泛参与了唇腭裂易感基因转录后蛋白质的SUMO化修饰.本文就SUMO化修饰及其在非综合征性唇腭裂发病中的意义作一.
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| 关 键 词： | 小遍在蛋白质样修饰物 修饰 非综合征性 唇腭裂 |
Role of small ubiquitin like modifier in etiology of nonsyndromic cleft lip and palate |
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| LIAO Li-shu,MENG Tian,ZHENG Qian,SHI Bing. Role of small ubiquitin like modifier in etiology of nonsyndromic cleft lip and palate[J]. Journal of International Stomatology, 2009, 36(1) |
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| Authors: | LIAO Li-shu MENG Tian ZHENG Qian SHI Bing |
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| Affiliation: | Dept. of Cleft Lip and Palate Surgery;West China College of Stomatology;Sichuan University;Chengdu 610041;China |
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| Abstract: | According to the proteomics, post-translational modification of proteins by small ubiquitin like modifier (SUMO) have many and variable consequences and have a key role in regulating and expanding the diversity of function in the proteome. A family member of SUMO, SUMO-1 participated most of the post-translational modifi-cation of proteins related to cleft lip and palate. |
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| Keywords: | small ubiquitin like modifier modification nonsyndromic cleft lip and palate |
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