Anti-Xa activity after subcutaneous administration of dalteparin in ICU patients with and without subcutaneous oedema: a pilot study |
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| Authors: | Mirjam K Rommers Netty Van Der Lely Toine CG Egberts Patricia MLA van den Bemt |
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| Affiliation: | (1) Hospital Pharmacy Midden-Brabant; TweeSteden Hospital and St Elisabeth Hospital, Tilburg, the Netherlands;(2) Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands;(3) Department of Intensive Care, St Elisabeth Hospital, Tilburg, the Netherlands;(4) Department of Pharmaco-epidemiology and Pharmacotherapy Utrecht, Institute for Pharmaceutical Sciences, Utrecht University, the Netherlands |
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| Abstract: | Introduction Intensive care unit (ICU) patients often suffer from subcutaneous oedema, due to administration of large fluid volumes and the underlying pathophysiological condition. It is unknown whether the presence of subcutaneous oedema impairs the absorption of dalteparin, a low molecular weight heparin, when it is given by subcutaneous administration for venous thromboembolism prophylaxis. The objective of this study is to compare the anti-Xa activity of dalteparin after subcutaneous administration in ICU patients with and without subcutaneous oedema. |
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